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To prolong the life of a 2010 Nissan Murano used transmission, adequate maintenance is necessary after installation. Depending on driving patterns, replace the CVT fluid every 30,000 to 60,000 miles after starting using Nissan NS-2 or NS-3 certified fluids. Because CVTs are sensitive to pressure and heat, avoid towing or strong acceleration without adequate cooling systems. Frequent diagnostic scans can also assist in detecting problems before they become more serious. Even though it's not brand new, the 2010 Nissan Murano used transmission may endure for years if properly cared for. Your best line of defense against potential breakdowns is routine treatment.