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Carpal Tunnel Syndrome Symptoms - Carpal tunnel syndrome is a condition that occurs when the median nerve, which runs through the wrist, becomes compressed or irritated. Common symptoms of carpal tunnel syndrome include: Numbness or tingling in the thumb, index finger, middle finger, and part of the ring finger. Hand weakness or difficulty gripping objects. Pain or discomfort that radiates up the forearm or to the shoulder. Increased symptoms at night or upon waking up. Sensation changes in the affected fingers, such as a feeling of swelling or clumsiness. If you experience these symptoms, it's advisable to consult a healthcare professional, who may recommend treatments such as wrist splints